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William F. Blakely

Medical & Rescue Service Research & Development United States of America

Dr. William F. Blakely


Future Forces Forum Future Forces Exhibition 2016 World CBRN & Medical Congress (CEBIRAM) 2016 Future Soldier Systems Conference (FSSC) 2016 Medical Workshop 2016

Senior Scientist – Radiation Biodosimetry
Armed Forces Radiobiology Research Institute, Uniformed Sevices University of Health Sciences


Presentation

The Trends and Challenges in Radiobiology: Applications in Radiological Medical Countermeasures

Since the four coordinated terrorist attacks on 11 September 2001, there has been a scientific renaissance of international efforts resulting in enhancements in radiological medical countermeasures both in radiation diagnostics and the development of drugs and new treatment strategies for mitigation and treatment of radiation injuries. The scope of multiple parameter radiation biodosimetry has expanded beyond radiation dose assessment by conventional clinical signs and symptoms, hematology, and cytogenetic assays to include use of molecular biomarkers based on gene expression and blood plasma proteomic targets to rapidly assess both radiation dose and injury. Point-of-care as well as laboratory diagnostic devices permitting rapid and high-throughput analysis have been developed. There has also been a paradigm shift in treatment approaches from the use of radioprotectant drugs, often used at near toxic dosages, to the use of small molecules that target specific pathways to exert beneficial consequences both in organ recovery and survival.


Curriculum Vitae

Education:

Senior Scientist, Biological Dosimetry Research Group, Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University of the Health Sciences (USUHS)

Assistant Professor (Appointed 2000), Environmental and Occupational Health Division, Preventive Medicine/Biometrics (PMB), School of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD

Ph.D., University of Illinois at Urbana-Champaign, Radiation Biology, 1980.

M.S., University of Illinois at Urbana-Champaign, Physiology, 1976.

B.A., San Diego State University, Zoology (Major)/Chemistry (Minor), 1974.

Professional Experience:

  • Member, Medical Radiological Advisory Team (MRAT), AFRRI, Bethesda, MD
  • Project Manager, radiation casualty management software, Biodosimetry Assessment Tool (BAT) and First-responder Radiological Assessment Triage (FRAT)
  • Senior Science Advisor, Radiation Emergency Accident Center/Training Site, Oak Ridge, TN
  • Member, Radiological Advisory Committee (RAC), New York City Department of Health and Mental Hygiene (DOHMH) New York, New York
  • Member of National Council of Radiation Protection and Measurements (NCRP), member of PAC-6 – Radiation Measurements and Dosimetry
  • Representative to ISO TC85/SC2 (Radiation Protection) Working Group 18 (Performance criteria for Service Laboratories performing Biological Dosimetry by Cytogenetics)
  • Member of BioDoseNet, World Health Organization
  • Member of the International Atomic Energy Agency (IAEA) Biodosimetry Working Group revising the manual for dose assessment by cytogenetics
  • Council Member, International Association of Biological and EPR Radiation Dosimetry (IABERD)

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