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Michal Kohout

Research & Development Czech Republic

Mr. Michal Kohout Ph.D.


Future Forces Forum Future Forces Exhibition 2016 World CBRN & Medical Congress (CEBIRAM) 2016

Assistant professor
Department of Organic Chemistry, University of Chemistry and Technology Prague


Presentation

Chiral Separation of Pharmaceuticals and New Synthetic Drugs on Chiral Ion Exchangers

POSTER: A unique class of chiral ion exchanger type selectors and derived chiral stationary phases (CSPs) have been designed and developed to separate chromatographically enantiomers of ionised substances. These can be derived from chiral acids, bases or amphoteric compounds. In this work, methods to enantiomerically separate several important biologically active substances will be presented. Using our set-up, mefloquine (the active substance of antimalarial Lariam) can be efficiently resolved. The control of this antimalarial is of the eminent importance; the erythro-(+)-enantiomer exhibit higher antimalarial activity and lower side effects (depression, etc.) comparing to the erythro-(-)-enantiomer. Similar differences in metabolic pathways are expected for enantiomers of frequently abused new synthetic drugs. Newly developed methods that allows for efficient chiral analysis of these substances and their metabolites are presented.


Curriculum Vitae

Education:

M.Sc. degree (2005) – Department of Organic Chemistry, University of Chemistry and Technology

Ph.D. degree (2009) – Department of Organic Chemistry, University of Chemistry and Technology

 

Professional Experience:

2008-2009 assistant, Department of Organic Chemistry, University of Chemistry and Technology

2009-2010 assistant professor, Department of Organic Chemistry, University of Chemistry and Technology

2010-2012 university assistant (post-doc), Department of Analytical Chemistry, University of Vienna

2012-now  assistant professor, Department of Organic Chemistry, University of Chemistry and Technology

 

Short term stays

2006-2008  three short term COST missions (five months in total) at the Department of Physics and Optics, Hungarian Academy of Sciences

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