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Jiří Kofránek

Medical & Rescue Service Research & Development Czech Republic

Assoc. Prof. Jiří Kofránek M.D.


Future Forces Forum Future Forces Exhibition 2016 Medical Workshop 2016

Head of Laboratory of Biocybernetics
1st Faculty of Medicine, Charles University


Presentation

PHYSIOMODEL – Large Scale Integrated Model of Human Physiology as a Core of a Sophisticated Medical Simulators

Models used as the theoretical foundation of sophisticated medical simulators must include mathematical models not only of individual physiological subsystems, but also their interconnections, thus forming a more complex unit. We have designed the large-scale integrative model of human physiology PHYSIOMODEL (www.physiomodel.org) as the reimplementation and extension of model HumMod 1.6 from Mississippi University (www.hummod.org). Our extensions in acid-base and blood gases transport improve the usability of the model during the modeling of complex disorders of acid-base, ionic, volume and osmotic homeostasis, which is very important for urgent medicinal statuses. The PHYSIOMODEL is an Open Source model written in Modelica language. Modelica is a new computer language that enables to create a transparent and legible model structure and therefore offers easier model modifications and extensions. The PHYSIOMODEL was used for our project “Virtual Patient”, where many theoretical scenarios can be simulated with a virtual environment like a computer game.


Curriculum Vitae

Since 1966 he was main researcher of many research and development grants (see http://patf-biokyb.lf1.cuni.cz/wiki/wiki/user/seznam_projektu). His research deals with mathematical modeling of physiological systems. He is founder of Laboratory of Biocybernetics, where he created a multidisciplinary team of physicians, mathematicians, computer scientists and artists (creating a user interface simulation models). His research deals with mathematical modeling of physiological systems. He is author or co-author more than 400 publications (see list of publications: http://patf-biokyb.lf1.cuni.cz/wiki/wiki/user/seznam_publikaci, see google profile: http://scholar.google.cz/citations?user=Qv8pd7MAAAAJ&hl=en). University Teacher: 1st Faculty of Medicine, Charles University: “Pathophysiology” Faculty of Electrical Engineering, Czech Technical University: “Modeling and Simulation” (Doc. Kofránek has also Associated Professor of Technical Cybernetics). Present Position: Department of pathophysiology, 1st Faculty of Medicine, Charles University, Associated Professor, Head of Laboratory of Biocybernetics.

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